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Mechanistic Biological Modeling

Mechanistic Biological Modeling

A College of Science Research Strategic Initiative

microscope room team using computer

‌Mechanistic modeling relies on the development of mathematical and computational models describing complex interactions between observed and unobserved variables. Together with empirical data, these models can be used to suggest, test, and validate hypotheses. Such models describe, explain, and quantify the cause and effect interactions between inputs and outputs. They go beyond forecasting an outcome; they suggest the biological mechanism underlying the emergence of observed outcomes. Once validated based on experimental or empirical data, these models can be used to guide investigations and to anticipate outcome in situations where experiments are difficult or expensive.
At every scale of biology – from the interaction of molecules to the interaction of species – mechanistic mathematical and computational models have become an essential tool to elucidate emergent behavior, highlight fundamental gaps in understanding, make predictions, and design optimal experiments to test such predictions.

The Mechanistic Biological Modeling group at Virginia Tech involves investigators from many departments.

Members of the Mechanistic Biological Modeling Group

Anand Banerjee headshot

Anand Banerjee

Academy of Integrated Science

Mathematical/Computational modeling of cell cycle checkpoints.

William Baumann

William Baumann

William Baumann

Electrical and Computer Engineering

Mathematical modeling of cancer

GBCB Faculty Member Jing Chen

Jing Chen

Department of Biological Sciences

Mathematical modeling of cellular processes

Lauren Childs

Lauren Childs

Department of Mathematics

Mathematical and computational modeling of biological systems

Daniela Cimini

Daniela Cimini, Associate Professor of Biological Sciences

Daniela Cimini

Department of Biological Sciences

Cell division and chromosome number alterations

Stanca Ciupe

Stanca Ciupe portrait

Stanca Ciupe

Department of Mathematics

Host dynamics of viral infections, theoretical immunology, and multi-scale disease modeling

Nisha Duggal

Nisha Duggal portrait

Nisha Duggal

Department of Biomedical Sciences and Pathobiology

Transmission and pathogenesis of emerging viruses

Gillian Eastwood

Gillian Eastwood portrait

Gillian Eastwood

Department of Entomology

OneHealth-focused vector-borne disease ecology

Silke Hauf

Silke Hauf is one of the VBI Fellows.

Silke Hauf

Department of Biological Sciences

Molecular mechanisms of accurate cell division

Dana Hawley

Dana Hawley portrait

Dana Hawley

Department of Biological Sciences

Ecology and evolution of infectious diseases

Joe Hoyt Headshot

Joe Hoyt

Department of Biological Sciences

Disease ecology and conservation

Laura Hungerford

Portrait of Laura Hungerford

Laura Hungerford

Department of Population Health Sciences

Using epidemiologic methods, mathematical modeling, and spatial analyses to study the risk of disease transmission

Leah Johnson

Leah Johnson portrait

Leah Johnson

Quantitative ecological dynamic

Shihoko Kojima. October 03, 2019. Fralin Life Sciences Institute. Personnel Photo. Photo Credit: Photo © Ivan Morozov, Fralin Life Sciences Institute. www.fralin.vt.edu

Shihoko Kojima. 2019. Fralin Life Sciences Institute Personnel Photo.

Shihoko Kojima

Department of Biological Sciences

Mammalian circadian biology

Liwu Li

Dr. Liwu Li, BioSci; Fralin Biotechnology research lab

Liwu Li

Department of Biological Sciences

Molecular signaling circuits modulating innate memory and inflammation

Alexey Onufriev

GBCB Faculty Member Alexey Onufriev

Alexey Onufriev

Departments of Computer Science and Physics

Theoretical and computational investigation of biomolecular systems, including 3D genome organization.

Pavel Kraikivski

Pavel Kraikivski portrait

Pavel Kraikivski

Academy of Integrated Science

Modeling the molecular networks regulating cell growth and division

Kate Langwig

Langwig portrait in dark Torgersen Bridge library.

Kate Langwig

Department of Biological Sciences

Infectious disease ecology

Cassidy Rist

Cassidy Rist portrait

Cassidy Rist

Department of Population Health Sciences

Economic evaluation of One Health approaches to infectious disease control and elimination

Omar Saucedo

Omar Saucedo portrait

Omar Saucedo

Department of Mathematics

Mathematical modeling of infectious diseases

Igor Sharakhov

image of igor sharakhov with a microscope in his lab

Igor Sharakhov

Department of Entomology

The 3D genome organization in fruit flies and mosquitoes

Alexey Onufriev

image of jake tu in his lab

Jake Tu

Department of Biochemistry

Molecular mechanisms of sex-determination in mosquitoes; Control of mosquito-borne infectious diseases by selectively targeting the biting females

Clement Vinauger

ClementVinauger

Clement Vinauger

Department of Biochemistry

Molecular and neural basis of mosquito behavior